Qnomx Insight
The NGS interpretation workflow revolution that unlocks your lab's full potential
Run higher caseloads at better margins, without burning out the experts you already have. Qnomx Insight automates the most burdensome part of NGS analysis, from variant filtering through evidence consolidation to annotation, and drafts patient-specific annotations ready for review and sign-off. Upload a VCF, get a defensible, audit-ready draft.
See Qnomx Insight on a real caseARID2p.V1589INC_000012.12
Mapped disease 'Melanoma' to OncoKB tumour type: MelanomaDemo annotation
End-to-end interpretation workflow, not point fixes
Genomicists use 10+ tools per case, because no competitor solves the real problem: synthesizing the most up to date information into complete, consistent, patient-specific annotations. Qnomx Insight automates the grunt work of the whole variant analysis stage, from VCF to draft annotation, with expert sign-off at the end.
Qnomx Insight works on its own. Paired with Qnomx Report, which drafts the clinician-ready document from your signed-off annotations, you get the full tertiary workflow from sequence to sign-off ready report, ready for your review. Each product stands alone, and the efficiency gains are largest when you run both.
What Qnomx Insight does
Filters and prioritises variants straight from your VCF
Consolidates evidence across leading sources including OncoKB, COSMIC, ClinVar, and the literature, in the context of each patient
Drafts patient-specific annotations from traceable evidence bases and methodologies, so your interpretation is reproducible across analysts and sites
Shows reasoning, confidence, and agreement across sources for every element, so variant analysts can quickly wrap up straightforward cases and focus their expertise on difficult ones
Your experts review, edit, and sign off. Interpretation and the final classification stay with them.
Why labs choose Qnomx Insight
Patient-specific from the first draft
Incumbents return generic information about the variant and analysts must manually fill in gaps and remove irrelevant data. You are stuck with repetitive grunt work like condensing pages of pembrolizumab approved indications from 17 to the one tumor type of your patient.
Qnomx Insight integrates that context from the start, so the draft your molecular pathologist opens is already about this patient, not a database entry to rework.
A drafted annotation, not a wall of lookups
At best, established tools line up database entries side by side; at worst analysts need to perform manual parallel manual lookups across databases and internal knowledge bases. Teams routinely delete a pre-assigned classification because the evidence behind it doesn't hold up. The synthesis is complex manual work left totally up to you.
Qnomx Insight does the reconciliation and brings it to your attention, then drafts the annotation, so your team reviews instead of assembles with hours of manual copy-paste busywork.
One reproducible standard across sites
Across labs, the same variant is classified differently roughly 66% of the time (Amendola et al. 2016).
With Qnomx Insight, your analysts and sites get consistent drafts instead of diverging on the same variant, with traceable, audit-ready timestamps and versions of every data source provided.
Clear when the evidence conflicts
Other tools force a call on a VUS or bury contradictory evidence.
Qnomx Insight flags ambiguity and defers. Clear-cut cases close fast, and your experts' time goes to the variants that actually need it.
Evidence chain visible, not black box
Other tools deliver opaque scores. Audit or accreditation questions mean reconstructing the rationale by hand.
Qnomx Insight delivers the draft with a cited evidence chain for every element. With that traceability, analysts trust the output, and the classification can be defended in the clinical report or explained later in a review.
What it means for your lab
More cases per analyst, with up to 85% less workload per case.
Scale capacity without hiring, so volume grows without competing for scarce specialists.
A team that stays, spending its hours on judgment instead of repetitive, manual database lookups.
Inquire today, deploy tomorrow
Qnomx Insight takes your VCF as input. No LIMS integration, no changes to your sequencing pipeline, and deployment in as little as 24 hours. Patient data is processed under strict security and privacy standards, with EU and Swiss data residency. No data goes through Silicon Valley models or servers.
Book a walkthrough on your own cases